Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GSK 2837808A | - |
Mus musculus | |
Sodium oxamate | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
muscle | - |
Mus musculus | - |
General Information | Comment | Organism |
---|---|---|
physiological function | lactate can fuel the bioenergetics of heart, muscle, and liver mitochondria. Lactate is just as effective as pyruvate at stimulating mitochondrial coupling efficiency. Inclusion of LDH and pyruvate dehydrogenase inhibitors abolishes respiration in mitochondria energized with lactate. Lactate also fueled mitochondrial ROS generation and is just as effective as pyruvate at stimulating H2O2 production. Lactate-induced ROS production is inhibited by both LDH and PDH inhibitors | Mus musculus |